Epigenomics | Stellvard Bioscience

Epigenomics Services

u r epigenomics services provide high-resolution insights into the mechanisms regulating gene expression without altering the underlying DNA sequence. We leverage advanced technologies such as bisulfite sequencing, ChIP-seq, and ATAC-seq, combined with dedicated bioinformatics pipelines, to analyze DNA methylation patterns, histone modifications, and chromatin structure. This enables a deeper understanding of development, disease progression, and environmental responses.

DNA Methylation Analysis

Quantitative profiling of 5-mC and 5-hmC marks across the genome using Whole Genome Bisulfite Sequencing (WGBS) or methylation arrays to study gene silencing and regulation.

Chromatin & Histone Profiling

Mapping DNA-protein interactions and histone modifications using ChIP-seq and CUT&RUN to identify active promoters, enhancers, and regulatory networks.

Chromatin Accessibility

Assessing open chromatin regions and nucleosome positioning using ATAC-seq to determine gene regulatory state and transcription factor binding accessibility. Assessing open chromatin regions and nucleosome positioning using ATAC-seq to determine gene regulatory state and transcription factor binding accessibility.

Epigenetic Regulation & Disease Insights

Understanding the epigenome is crucial for dissecting gene regulation mechanisms without altering the underlying DNA sequence. Our epigenomics services are key in oncology research, where aberrant DNA methylation and histone modifications drive tumor progression. We also support neuro-epigenetics and developmental biology research by mapping active and repressed chromatin states across various cellular lineages.